The purpose of this online registry is to collect information from a diverse group of institutions with different clinical practices to identify cases of Transfusion Related Acute Gut Injury (TRAGI). TRAGI is defined as Necrotizing Enterocolitis (NEC), which must include clinical symptomology as well as presence of pneumatosis on abdominal radiograph, that occurs within 48 hours of a PRBC transfusion. TRAGI is defined in the recent article "Transfusion–Related Acute Gut Injury: Necrotizing Enterocolitis in Very Low Birth Weight Neonates after Packed Red Blood Cell Transfusion.”


For further information, see the August 2012 edition of Seminars in Perinatology that is devoted to current thinking on the risks, benefits, and alternatives to neonatal red cell replacement.   Sem Perinatol, Transfusion Practices in Neonates: Risks, Benefits, and Alternatives, Guest Editor: E. F. LaGamma, 11 reports, August 36(4) 2012.


Entry of all cases of NEC are welcome and appreciated; both TRAGI as well as NEC unrelated to transfusion.  We suggest entering data at time of discharge to capture neonates' entire clinical course.


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TRAGI Registry

For any questions please contact: Edmund La Gamma, MD, email: edmund_lagamma@nymc.edu, telephone 914-493-8558, Division of Newborn Medicine, Maria Fareri Childrens's Hospital, New York Medical College, Valhalla, NY 10595

Access to patient medical records for research purposes requires either IRB approval or determination that the study is exempt as well as approval of a HIPAA waiver.  You, as a physician who is entering data for: “An Online World Registry for Transfusion Related Acute Gut Injury (TRAGI)”, initiated by Edmund LaGamma, MD from the New York Medical College, are required to review and, if appropriate, provide an affirmative response to the following statement.


As the physician accessing medical records for the purpose of entering data for the registry named above, I have obtained the following: (a) approval from my institution and/or the party with ownership of the relevant data; (b) IRB approval or notice of exemption from my institution; and (c) approval of a HIPAA Waiver.


If YES, Click here to continue.


If NO, please contact your IRB for approval to access the site.